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Drug sensitivity prediction for cancer cell lines based on pairwise kernels and miRNA profiles
Cancer cell lines comprise an important tool to design and evaluate new drug candidates. Prediction of in vivo drug response for cancer cell lines has become attractive due to recently issued large scale drug screen ...
Predicting drug activity by image encoded gene expression profiles
(Institute of Electrical and Electronics Engineers Inc., 2018-07-05)
Developing personalized cancer treatment procedures requires a prior knowledge on the effects of different drugs on cancer cell lines. While obtaining this information in vitro is a tedious task, the emergence of numerous ...
A comprehensive approach for validating p53 binding site predictions
(Institute of Electrical and Electronics Engineers Inc., 2017-10-20)
Predicting the locations of Response Elements (RE) has received considerable attention in the field of gene sequence analysis and bioinformatics. Protein53 (p53) has a prominent role in the cell cycle and cancer prevention; ...