Show simple item record

dc.contributor.authorKabay, Gözde
dc.contributor.authorMeydan, Ahmet Ersin
dc.contributor.authorKaleli Can, Gizem
dc.contributor.authorDemirci, Ceylan
dc.contributor.authorMutlu, Mehmet
dc.date.accessioned2019-05-23T05:48:44Z
dc.date.available2019-05-23T05:48:44Z
dc.date.issued2017-12
dc.identifier.citationKabay, G., Meydan, A. E., Can, G. K., Demirci, C., & Mutlu, M. (2017). Controlled release of a hydrophilic drug from electrospun amyloid-like protein blend nanofibers. Materials Science and Engineering: C, 81, 271-279.en_US
dc.identifier.issn0928-4931
dc.identifier.othernumber of pages 9
dc.identifier.urihttps://doi.org/10.1016/j.msec.2017.08.003
dc.identifier.urihttp://hdl.handle.net/20.500.11851/1022
dc.description.abstractIn this study, a controlled drug release platform, amyloid-like bovine serum albumin (AL-BSA) with ampicillin sodium salt (amp), was developed. To develop this platform, 5%, 10%, and 20% (w/w) ratios of amp:BSA were used with electrospinning to prepare nanofibers with average diameters of 132 +/- 69, 159 +/- 60, and 179 +/- 42 nm, respectively. Fourier transform infrared spectroscopy demonstrated that AL-BSA could entrap large amounts of drug inside the nanofibers, which was attributed to the antimicrobial activity of the released drug against Escherichia coli and Staphylococcus aureus. The amount of drug released was measured by UV-VIS spectrophotometry. The nanofibrous matrix of the electrospun membrane showed controlled release behavior in all samples. The transport mechanism was Fickian for the low ratio of amp:BSA (5% w:w). When the drug ratio was increased to > 10% (w:w), thicker fiber structures formed, suggesting that the drug traveled a longer distance to reach the fiber surface; thus, the mechanism of transport shifted from Fickian to non-Fickian.en_US
dc.language.isoengen_US
dc.publisherElsevier Science Bven_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectdrug releaseen_US
dc.subjectamyloid-like bovine serum albuminen_US
dc.subjectcontrolled releaseen_US
dc.subjectblend electrospinningen_US
dc.subjectampicillinen_US
dc.titleControlled release of a hydrophilic drug from electrospun amyloid-like protein blend nanofibersen_US
dc.typearticleen_US
dc.relation.journalMaterials Science & Engineering C-Materials For Biological Applicationsen_US
dc.contributor.departmentTOBB ETU, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.contributor.departmentTOBB ETÜ, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume81
dc.identifier.startpage271
dc.identifier.endpage279
dc.contributor.orcidhttps://orcid.org/0000-0001-7146-1937
dc.contributor.orcidhttps://orcid.org/0000-0002-8594-3459
dc.identifier.wosWOS:000410253800033
dc.identifier.scopus2-s2.0-85027517184
dc.contributor.tobbetuauthorMutlu, Mehmet
dc.contributor.tobbetuauthorKabay, Gözde
dc.identifier.PubMedIDPMID:28887973
dc.identifier.doi10.1016/j.msec.2017.08.003
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record