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dc.contributor.authorDemirkaya, K.
dc.contributor.authorCan Demirdöğen, Birsen
dc.contributor.authorTorun, Z. Oncel
dc.contributor.authorErdem, O.
dc.contributor.authorCirak, E.
dc.contributor.authorTunca, Y. M.
dc.identifier.citationDemirkaya, K., Demirdöğen, B. C., Torun, Z. Ö., Erdem, O., Çırak, E., & Tunca, Y. M. (2017). Brain aluminium accumulation and oxidative stress in the presence of calcium silicate dental cements. Human & experimental toxicology, 36(10), 1071-1080.en_US
dc.identifier.othernumber of pages 10
dc.description.abstractMineral trioxide aggregate (MTA) is a calcium silicate dental cement used for various applications in dentistry. This study was undertaken to test whether the presence of three commercial brands of calcium silicate dental cements in the dental extraction socket of rats would affect the brain aluminium (Al) levels and oxidative stress parameters. Right upper incisor was extracted and polyethylene tubes filled with MTA Angelus, MTA Fillapex or Theracal LC, or left empty for the control group, were inserted into the extraction socket. Rats were killed 7, 30 or 60 days after operation. Brain tissues were obtained before killing. Al levels were measured by atomic absorption spectrometry. Thiobarbituric acid reactive substances (TBARS) levels, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were determined using spectrophotometry. A transient peak was observed in brain Al level of MTA Angelus group on day 7, while MTA Fillapex and Theracal LC groups reached highest brain Al level on day 60. Brain TBARS level, CAT, SOD and GPx activities transiently increased on day 7 and then returned to almost normal levels. This in vivo study for the first time indicated that initial washout may have occurred in MTA Angelus, while element leaching after the setting is complete may have taken place for MTA Fillapex and Theracal LC. Moreover, oxidative stress was induced and antioxidant enzymes were transiently upregulated. Further studies to search for oxidative neuronal damage should be done to completely understand the possible toxic effects of calcium silicate cements on the brain.en_US
dc.publisherSage Publications Ltden_US
dc.subjectdental cementen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectmineral trioxide aggregateen_US
dc.subjectglutathione peroxidaseen_US
dc.titleBrain aluminium accumulation and oxidative stress in the presence of calcium silicate dental cementsen_US
dc.relation.journalHuman & Experimental Toxicologyen_US
dc.contributor.departmentTOBB ETU, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.contributor.departmentTOBB ETÜ, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.contributor.tobbetuauthorCan Demirdöğen, Birsen
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.relation.otherGulhane Military Medical Academy Research Project Fund [ARE-2013/39]

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