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dc.contributor.authorOzcelik, Aysun Turkanoglu
dc.contributor.authorCan Demirdöğen, Birsen
dc.contributor.authorDemirkaya, Şeref
dc.contributor.authorAdali, Orhan
dc.date.accessioned2019-05-23T05:48:45Z
dc.date.available2019-05-23T05:48:45Z
dc.date.issued2017-06
dc.identifier.citationÖzçelik, A. T., Demirdöğen, B. C., Demirkaya, Ş., & Adalı, O. (2017). Association of cytochrome P4502E1 and NAD (P) H: quinone oxidoreductase 1 genetic polymorphisms with susceptibility to large artery atherosclerotic ischemic stroke: a case–control study in the Turkish population. Neurological Sciences, 38(6), 1077-1085.en_US
dc.identifier.issn1590-1874
dc.identifier.othernumber of pages 9
dc.identifier.urihttps://doi.org/10.1007/s10072-017-2930-9
dc.identifier.urihttp://hdl.handle.net/20.500.11851/1039
dc.description.abstractStroke, a major cause of death and disability, is described as interruption or severe reduction of blood flow in cerebral arteries. Oxidative stress plays an important role in the pathogenesis of atherosclerosis and carotid atherosclerosis is a risk factor for stroke. Combination of multiple environmental and genetic risk factors is thought to increase stroke. Therefore, investigation of the polymorphisms of enzymes is of crucial importance to determine the molecular etiology of the disease. To test this hypothesis, we performed a case-control study in which we compared the distribution of CYP2E1 and NQO1 genotypes between 245 large artery atherosclerotic ischemic stroke patients and 145 controls, using PCR-RFLP. A significant difference was observed between stroke patients and controls with respect to the CYP2E1*5B genotype (odds ratio; OR 8.069, P = 0.011) and allele (OR 7.876, P = 0.011) distribution. However, this polymorphism was not a significant predictor of disease status in logistic regression analysis. NQO1*2 polymorphism genotype distribution was significantly different between patients and controls (P = 0.027) and heterozygote *1*2 genotype was found to be a protective factor against large artery atherosclerotic ischemic stroke in logistic regression analysis (OR 0.562, P = 0.018). This is the first study conducted regarding the association of CYP2E1 and NQO1 genetic polymorphisms and large artery atherosclerotic ischemic stroke risk in Turkish population.en_US
dc.language.isoengen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectturkish populationen_US
dc.subjectlarge artery atherosclerotic ischemic strokeen_US
dc.subjectpolymorphismen_US
dc.subjectnqo1en_US
dc.subjectcyp2e1en_US
dc.titleAssociation of cytochrome P4502E1 and NAD(P)H:quinone oxidoreductase 1 genetic polymorphisms with susceptibility to large artery atherosclerotic ischemic stroke: a case-control study in the Turkish populationen_US
dc.typearticleen_US
dc.relation.journalNeurological Sciencesen_US
dc.contributor.departmentTOBB ETU, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.contributor.departmentTOBB ETÜ, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume38
dc.identifier.issue6
dc.identifier.startpage1077
dc.identifier.endpage1085
dc.contributor.orcidhttps://orcid.org/0000-0002-1536-6123
dc.identifier.wosWOS:000403353900020
dc.identifier.scopus2-s2.0-85016412479
dc.contributor.tobbetuauthorCan Demirdöğen, Birsen
dc.identifier.PubMedIDPMID:28357584
dc.identifier.doi10.1007/s10072-017-2930-9
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR


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