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dc.contributor.authorErişken, Cevat
dc.contributor.authorKalyon Dilhan M.
dc.contributor.authorZhou J.
dc.contributor.authorKim SahngG.
dc.contributor.authorMao Jeremy J.
dc.date.accessioned2019-07-08T13:29:35Z
dc.date.available2019-07-08T13:29:35Z
dc.date.issued2015-08
dc.identifier.citationErisken, C., Kalyon, D. M., Zhou, J., Kim, S. G., & Mao, J. J. (2015). Viscoelastic properties of dental pulp tissue and ramifications on biomaterial development for pulp regeneration. Journal of endodontics, 41(10), 1711-1717.en_US
dc.identifier.issn0099-2399
dc.identifier.othernumber of pages 7
dc.identifier.urihttps://dx.doi.org/10.1016/j.joen.2015.07.005
dc.identifier.urihttp://hdl.handle.net/20.500.11851/1801
dc.description.abstractIntroduction: A critical step in biomaterial selection effort is the determination of material as well as the biological properties of the target tissue. Previously, the selection of biomaterials and carriers for dental pulp regeneration has been solely based on empirical experience. Methods: In this study, first, the linear, viscoelastic material functions and compressive properties of miniature pig dental pulp were characterized using small-amplitude oscillatory shear and uniaxial compression at a constant rate. They were then compared with the properties of hydrogels (ie, agarose, alginate, and collagen) that are widely used in tissue regeneration. Results: The comparisons of the linear viscoelastic material functions of the native pulp tissue with those of the 3 hydrogels revealed the gel-like behavior of the pulp tissue over a relatively large range of time scales (ie, over the frequency range of 0.1-100 rps). At the constant gelation agent concentration of 2%, the dynamic properties (ie, storage and loss moduli and the tan delta) of the collagen-based gel approached those of the native tissue. Under uniaxial compression, the peak normal stresses and compressive moduli of the agarose gel were similar to those of the native tissue, whereas alginate and collagen exhibited significantly lower compressive properties. Conclusions: The linear viscoelastic and uniaxial compressive properties of the dental pulp tissue reported here should enable the more appropriate selection of biogels for dental pulp regeneration via the better tailoring of gelation agents and their concentrations to better mimic the dynamic and compressive properties of native pulp tissue.en_US
dc.language.isoengen_US
dc.publisherElsevier Inc.en_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiomaterialen_US
dc.subject compressionen_US
dc.subject pulpen_US
dc.subject regenerationen_US
dc.subject toothen_US
dc.subject viscoelasticen_US
dc.titleViscoelastic properties of dental pulp tissue and ramifications on biomaterial development for pulp regenerationen_US
dc.typearticleen_US
dc.relation.journalJournal of Endodonticsen_US
dc.contributor.departmentTOBB ETU, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.contributor.departmentTOBB ETÜ, Mühendislik Fakültesi,Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume41
dc.identifier.issue10
dc.identifier.startpage1711
dc.identifier.endpage1717
dc.contributor.orcidhttps://orcid.org/0000-0002-6337-8022
dc.identifier.wosWOS:000362386100022
dc.identifier.scopus2-s2.0-84942552108
dc.contributor.tobbetuauthorErişken, Cevat
dc.contributor.YOKid222224
dc.identifier.PubMedIDPMID:26321063
dc.identifier.doi10.1016/j.joen.2015.07.005
dc.contributor.wosresearcherIDP-7850-2014
dc.contributor.ScopusAuthorID6506431371
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR


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