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dc.contributor.authorGao, Shang
dc.contributor.authorChen, Alan
dc.contributor.authorRahmani, Ali
dc.contributor.authorZeng, Jia
dc.contributor.authorTan, Mehmet
dc.contributor.authorAlhajj, Reda
dc.contributor.authorRokne, Jon
dc.contributor.authorDemetrick, Douglas
dc.contributor.authorWei, Xiaohui
dc.date.accessioned2019-07-10T14:42:46Z
dc.date.available2019-07-10T14:42:46Z
dc.date.issued2016
dc.identifier.citationGao, S., Chen, A., Rahmani, A., Zeng, J., Tan, M., Alhajj, R., ... & Wei, X. (2016). Multi-scale modularity and motif distributional effect in metabolic networks. Current Protein and Peptide Science, 17(1), 82-92.en_US
dc.identifier.issn1389-2037
dc.identifier.urihttp://www.eurekaselect.com/135160/article
dc.identifier.urihttp://hdl.handle.net/20.500.11851/2023
dc.description.abstractMetabolism is a set of fundamental processes that play important roles in a plethora of biological and medical contexts. It is understood that the topological information of reconstructed metabolic networks, such as modular organization, has crucial implications on biological functions. Recent interpretations of modularity in network settings provide a view of multiple network partitions induced by different resolution parameters. Here we ask the question: How do multiple network partitions affect the organization of metabolic networks? Since network motifs are often interpreted as the super families of evolved units, we further investigate their impact under multiple network partitions and investigate how the distribution of network motifs influences the organization of metabolic networks. We studied Homo sapiens, Saccharomyces cerevisiae and Escherichia coli metabolic networks; we analyzed the relationship between different community structures and motif distribution patterns. Further, we quantified the degree to which motifs participate in the modular organization of metabolic networks.en_US
dc.description.sponsorshipNational Natural Science Foundation of China (NSFC) [61170004]; Key Science and Technology Research Project of Science and Technology Department of Jilin Province [20140204013GX]
dc.language.isoengen_US
dc.publisherBENTHAM Science Publ. Ltd.en_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMetabolic networken_US
dc.subjectnetwork communityen_US
dc.subjectmulti-scale modularityen_US
dc.subjectmotifsen_US
dc.titleMulti-Scale Modularity and Motif Distributional Effect in Metabolic Networksen_US
dc.typearticleen_US
dc.relation.journalCurrent Protein and Peptide Scienceen_US
dc.contributor.departmentTOBB ETU, Faculty of Engineering, Department of Computer Engineeringen_US
dc.contributor.departmentTOBB ETÜ, Mühendislik Fakültesi, Bilgisayar Mühendisliği Bölümütr_TR
dc.identifier.volume17
dc.identifier.issue1
dc.identifier.startpage82
dc.identifier.endpage92
dc.contributor.orcidhttps://orcid.org/0000-0002-1741-0570
dc.identifier.wosWOS:000365803000011
dc.identifier.scopus2-s2.0-84953404943
dc.contributor.tobbetuauthorTan, Mehmet
dc.contributor.YOKid110845
dc.identifier.doi10.2174/1389203716666150923104603
dc.contributor.wosresearcherIDI-2328-2019
dc.contributor.ScopusAuthorID36984623900
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR


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