Show simple item record

dc.contributor.authorCan Demirdöğen, Birsen
dc.contributor.authorKoçan Akçin, Canan
dc.contributor.authorGöksoy, Ezgi
dc.contributor.authorYakar, Gizem
dc.contributor.authorÖztepe, Tuğçe
dc.contributor.authorDemirkaya-Budak, Sinem
dc.contributor.authorOflaz, Sinan
dc.date.accessioned2019-12-25T14:15:47Z
dc.date.available2019-12-25T14:15:47Z
dc.date.issued2019-10
dc.identifier.citationDemirdöğen, B. C., Akçin, C. K., Göksoy, E., Yakar, G., Öztepe, T., Demirkaya-Budak, S., & Oflaz, S. (2019). Paraoxonase 1 (PON1) promoter (? 107T/C) and coding region (192Q/R and 55L/M) genetic variations in pseudoexfoliation syndrome and pseudoexfoliative glaucoma risk. Graefe's Archive for Clinical and Experimental Ophthalmology, 257(10), 2257-2270.en_US
dc.identifier.issn0721-832X
dc.identifier.urihttps://doi.org/10.1007/s00417-019-04408-w
dc.identifier.urihttp://hdl.handle.net/20.500.11851/2889
dc.description.abstractPurpose: Pseudoexfoliation syndrome (PEX) is characterized by the accumulation of microscopic extracellular material in the anterior chamber of the eye and can lead to the development of pseudoexfoliative glaucoma (PEG) in some patients. The pathogenesis of PEX is not fully understood, and there are no objective biomarkers for its early diagnosis. Recent research has indicated that oxidative stress and inflammation might play a role in the pathophysiology of the production of pseudoexfoliation material. Therefore, in the present study, we aimed to analyze the possible association between three genetic variants of paraoxonase 1 (PON1), a well-recognized antioxidant and anti-inflammatory enzyme, and PEX/PEG. Methods: The study population consisted of patients with PEX (n = 150), patients with PEG (n = 150), and control subjects (n = 150). PON1 ?107T/C, 192Q/R, and 55L/M genotypes were determined using PCR followed by restriction fragment length polymorphism analysis. The correlation between these genetic alterations and clinical visual characteristics was also investigated. Results: The minor allele frequencies and genotype distributions of PON1 did not differ significantly between the PEG, PEX, and control groups. Moreover, PON1 genotypes did not significantly influence visual clinical parameters in stratification analysis. On the other hand, in correlation analysis, pattern standard deviation was significantly correlated with the ?107T/C genotypes in PEX group. In addition, intraocular pressure was correlated with the 55L/M genotypes and mean deviation was correlated with the ?107T/C genotypes in the control group. Furthermore, intraocular pressure was significantly inversely correlated with sex (r = ? 0.116, P = 0.011) in the overall study group. Logistic regression analysis showed that having a PON1 ?107TC or CC genotype is significantly associated with PEX (OR = 1.909, P = 0.020). Conclusions: This study, for the first time, analyzed the relationship between PON1 genetic variants, clinical visual parameters, and PEX/PEG. The results indicated a possible role for the PON1 promoter variant in PEX.en_US
dc.language.isoengen_US
dc.publisherSpringer Berlin Heidelbergen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIOPen_US
dc.subjectMean deviationen_US
dc.subjectPattern standard deviationen_US
dc.subjectPolymorphismen_US
dc.subjectVisual field scoreen_US
dc.titleParaoxonase 1 (PON1) promoter (?107T/C) and coding region (192Q/R and 55L/M) genetic variations in pseudoexfoliation syndrome and pseudoexfoliative glaucoma risken_US
dc.typearticleen_US
dc.typeinfo:eu-repo/semantics/acceptedVersion
dc.relation.journalGraefe's Archive for Clinical and Experimental Ophthalmologyen_US
dc.contributor.departmentTOBB ETU, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.contributor.departmentTOBB ETÜ, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume257
dc.identifier.issue10
dc.identifier.startpage2257
dc.identifier.endpage2270
dc.relation.tubitakinfo:eu-repo/grantAgreement/TÜBİTAK/SBAG/315S190en_US
dc.contributor.orcidhttps://orcid.org/0000-0002-1536-6123
dc.identifier.wosWOS:000496711200021
dc.identifier.scopus2-s2.0-85069704085
dc.contributor.tobbetuauthorCan Demirdöğen, Birsen
dc.identifier.PubMedIDPMID:31292763
dc.identifier.doi10.1007/s00417-019-04408-w
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record