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Effects of Systemic and Local Caffeine on Vessel Diameter, Anastomosis Patency, and Intimal Hyperplasia in the Rat

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dc.contributor.author Sakarya, Ahmet Hamdi
dc.contributor.author Uzun, Hakan
dc.contributor.author Turkkani, Ayten
dc.contributor.author Cakar, Ayse Nur
dc.contributor.author Hsieh, Yun-Huan
dc.contributor.author Ustun, Galip Gencay
dc.contributor.author Safak, Tunc
dc.date.accessioned 2019-12-30T07:28:21Z
dc.date.available 2019-12-30T07:28:21Z
dc.date.issued 2019
dc.identifier.citation Sakarya, A. H., Uzun, H., Türkkanı, A., Çakar, A. N., Hsieh, Y. H., Üstün, G. G., & Şafak, T. (2019). Effects of Systemic and Local Caffeine on Vessel Diameter, Anastomosis Patency, and Intimal Hyperplasia in the Rat. Journal of reconstructive microsurgery, 35(04), 244-253. en_US
dc.identifier.issn 0743-684X
dc.identifier.other 10
dc.identifier.uri https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1672130
dc.identifier.uri http://hdl.handle.net/20.500.11851/3256
dc.description.abstract Background The use of caffeine is not recommended prior to elective microsurgery due to its demonstrated negative effects on vessel anastomosis by the presumed sympathomimetic induction of vasoconstriction. In this study, we aimed to elucidate the systemic and local effects of caffeine on vessel diameter, anastomosis patency, and degree of intimal hyperplasia during the healing process. Methods Twenty-five rats were randomly assigned to five groups: (1) negative control, (2) preoperative systemic caffeine, (3) postoperative systemic caffeine, (4) perioperative systemic caffeine, and (5) a local caffeine group. Both the right and left femoral arteries were used. Ten anastomoses were performed per group. The arterial diameter was measured by micrometer, anastomosis patency was assessed surgically and histologically, and the histological examination was conducted 3 weeks postoperatively to determine intimal hyperplasia. Results The overall patency rate was 96%. Mild vasoconstriction was observed in the systemic caffeine groups (statistically insignificant); however, there were no negative effects on anastomosis patency. Local caffeine irrigation resulted in significant vasodilatation in the local caffeine group ( p =0.001); a similar effect was not observed in the other groups. There was a significant decrease in the intima/media ratio in the local caffeine group ( p <0.01), when compared with the control and systemic caffeine groups. No other intima/media ratio differences were observed among other comparison groups. Conclusion The systemic administration of caffeine, although statistically insignificant, has an observable effect on vasoconstriction. However, it does not appear to have negative effects on anastomosis patency regardless of its application period (pre-, post-, or perioperatively). The local application of caffeine resulted in considerable vasodilatation as opposed to the vasoconstriction effect in the systemic caffeine groups. Decreased intimal hyperplasia at the anastomosis edge, and antifibrotic properties in the surgical field were also observed in this group. Histologically, the local caffeine group demonstrated an additional beneficial effect on anastomosis remodeling. en_US
dc.language.iso eng en_US
dc.publisher THIEME MEDICAL PUBL INC en_US
dc.rights info:eu-repo/semantics/closedAccess
dc.subject caffeine en_US
dc.subject anastomosis patency en_US
dc.subject intimal hyperplasia en_US
dc.title Effects of Systemic and Local Caffeine on Vessel Diameter, Anastomosis Patency, and Intimal Hyperplasia in the Rat en_US
dc.type article en_US
dc.relation.journal JOURNAL OF RECONSTRUCTIVE MICROSURGERY en_US
dc.contributor.department TOBB ETÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü tr_TR
dc.contributor.department TOBB ETU, Faculty of Medicine, Department of Basic Medical Sciences en_US
dc.identifier.volume 35
dc.identifier.issue 4
dc.identifier.startpage 244
dc.identifier.endpage 253
dc.identifier.wos WOS:000466147000002
dc.contributor.tobbetuauthor Çakar, Ayse Nur
dc.contributor.YOKid 182011
dc.identifier.doi 10.1055/s-0038-1672130
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı tr_TR


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