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Photobiomodulation with polychromatic light increases zone 4 survival of transverse rectus abdominis musculocutaneous flap

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dc.contributor.author Calis, Mert
dc.contributor.author Demirtas, Tugrul Tolga
dc.contributor.author Sert, Gokhan
dc.contributor.author Irmak, Gulseren
dc.contributor.author Gumusderelioglu, Menemse
dc.contributor.author Turkkani, Ayten
dc.contributor.author Cakar, Ayse Nur
dc.contributor.author Ozgur, Figen
dc.date.accessioned 2019-12-30T07:28:21Z
dc.date.available 2019-12-30T07:28:21Z
dc.date.issued 2019
dc.identifier.citation Calis, M., Demirtas, T. T., Sert, G., Irmak, G., Gumusderelioglu, M., Turkkani, A., ... & Ozgur, F. (2019). Photobiomodulation with polychromatic light increases zone 4 survival of transverse rectus abdominis musculocutaneous flap. Lasers in surgery and medicine. en_US
dc.identifier.issn 0196-8092
dc.identifier.other 12
dc.identifier.uri https://onlinelibrary.wiley.com/doi/full/10.1002/lsm.23063
dc.identifier.uri http://hdl.handle.net/20.500.11851/3257
dc.description.abstract Objective The aim of this study was to evaluate the effect of relatively novel approach of application of polychromatic light waves on flap survival of experimental musculocutaneous flap model and to investigate efficacy of this modality as a delay procedure to increase vascularization of zone 4 of transverse rectus abdominis musculocutaneous (TRAM) flap. Methods Twenty-one Wistar rats were randomized and divided into 3 experimental groups (n = 7 each). In group 1 (control group), after being raised, the TRAM flap was sutured back to its bed without any further intervention. In group 2 (delay group), photobiomodulation (PBM) was applied for 7 days as a delay procedure, before elevation of the flap. In group 3 (PBM group), the TRAM flap was elevated, and PBM was administered immediately after the flap was sutured back to its bed for therapeutic purpose. PBM was applied in 48 hours interval from 10 cm. distance to the whole abdominal wall both in groups 2 and 3 for one week. After 7 days of postoperative follow-up, as the demarcation of necrosis of the skin paddle was obvious, skin flap survival was further evaluated by macroscopic, histological and microangiographic analysis. Results The mean percentage of skin flap necrosis was 56.17 +/- 23.68 for group 1, 30.92 +/- 17.46 for group 2 and 22.73 +/- 12.98 for group 3 PBM receiving groups 2 and 3 revealed less necrosis when compared to control group and this difference was statistically significant. Vascularization in zone 4 of PBM applied groups 2 and 3 was higher compared to group 1 (P = 0.001). Acute inflammation in zone 4 of group 1 was significantly higher compared to groups 2 and 3 (P = 0.025). Similarly, evaluation of zone 1 of the flaps reveled more inflammation and less vascularization among the samples of the control group (P = 0.006 and P = 0.007, respectively). Comparison of PBM receiving two groups did not demonstrate further difference in means of vascularization and inflammation density (P = 0.259). Conclusion Application of PBM in polychromatic fashion enhances skin flap survival in experimental TRAM flap model both on preoperative basis as a delay procedure or as a therapeutic approach. Lasers Surg. 51:538-549, 2019. (c) 2019 Wiley Periodicals, Inc. en_US
dc.language.iso eng en_US
dc.publisher WILEY en_US
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Photobiomodulation en_US
dc.subject low level laser therapy en_US
dc.subject polychromatic light en_US
dc.subject transverse rectus abdominis flap en_US
dc.subject flap delay en_US
dc.subject zone 4 necrosis en_US
dc.subject wound regeneration en_US
dc.title Photobiomodulation with polychromatic light increases zone 4 survival of transverse rectus abdominis musculocutaneous flap en_US
dc.type article en_US
dc.relation.journal LASERS IN SURGERY AND MEDICINE en_US
dc.contributor.department TOBB ETÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü tr_TR
dc.contributor.department TOBB ETU, Faculty of Medicine, Department of Basic Medical Sciences en_US
dc.identifier.volume 51
dc.identifier.issue 6
dc.identifier.startpage 538
dc.identifier.endpage 549
dc.identifier.wos WOS:000474654100009
dc.contributor.tobbetuauthor Çakar, Ayse Nur
dc.contributor.YOKid 182011
dc.identifier.doi 10.1002/lsm.23063
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı tr_TR


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