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dc.contributor.authorTurkmen, Osman
dc.contributor.authorBasaran, Derman
dc.contributor.authorKaralok, Alper
dc.contributor.authorKimyon, Gunsu Comert
dc.contributor.authorTasci, Tolga
dc.contributor.authorUreyen, Isin
dc.contributor.authorTulunay, Gökhan
dc.contributor.authorTuran, Taner
dc.identifier.citationTürkmen, O., Başaran, D., Karalök, A., Kimyon, G. C., Taşçı, T., Üreyen, I., ... & Turan, T. (2018). Prognostic effect of isolated paraaortic nodal spread in endometrial cancer. Journal of the Turkish German Gynecological Association, 19(4), 201.en_US
dc.description.abstractObjective: To evaluate the prognostic effect of isolated paraaortic lymph node metastasis in endometrial cancer (EC). Material and Methods: This retrospective study included patients with FIGO 2009 stage IIIC2 disease due to isolated paraaortic lymph node metastasis (LNM). Patients with sarcomatous histology, synchronous gynecologic cancers and patients with concurrent pelvic lymph node metastases or patients that have intraabdominal tumor spread were excluded. Kaplan-Meier method was used for calculation of progression free survival (PFS) and overall survival. Results: One thousand six hundred and fourteen patients were operated for EC during study period. Nine hundred and sixty-one patients underwent lymph node dissection and 25 (2.6%) were found to have isolated LNM in paraaortic region and these constituted the study cohort. Twenty (80%) patients had endometrioid EC. Median number of retrieved lymph nodes from pelvic region and paraaortic region was 21.5 (range: 5-41) and 34.5 (range: 1-65), respectively. Median number of metastatic paraaortic nodes was 1 (range: 1-32). The median follow-up time was 15 months (range 5-94). Seven (28%) patients recurred after a median of 20 months (range, 3-99) from initial surgery. Three patients recurred only in pelvis, one patient had upper abdominal spread and 3 had isolated extraabdominal recurrence. Involvement of uterine serosa, positive peritoneal cytology and presence of adnexal metastasis were significantly associated with diminished PFS (p<0.05). Conclusion: The presence of serosal involvement or adnexal involvement is as important as gross peritoneal spread and is related with poor survival in patients with isolated paraaortic nodal spread in EC. Chemotherapy should be the mainstay of treatment in this patient cohort which may eradicate systemic tumor spread.en_US
dc.publisherGalenos Yayıncılıken_US
dc.subjectEndometrial canceren_US
dc.subjectparaaortic lymph node metastasisen_US
dc.subjectserosal involvementen_US
dc.titlePrognostic effect of isolated paraaortic nodal spread in endometrial canceren_US
dc.relation.journalJournal of the Turkish German Gynecology Associationen_US
dc.contributor.departmentTOBB ETU, Faculty of Medicine, Department of Surgical Sciencesen_US
dc.contributor.departmentTOBB ETÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümütr_TR
dc.contributor.tobbetuauthorTulunay, Hakkı Gökhan
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR

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