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Qualitative/Chemical Analyses of Ankaferd Hemostat and Its Antioxidant Content in Synthetic Gastric Fluids

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dc.contributor.author Koluman, Ahmet
dc.contributor.author Akar, Nejat
dc.contributor.author Malkan, Umit Y.
dc.contributor.author Haznedaroglu, Ibrahim C.
dc.date.accessioned 2020-02-13T07:08:33Z
dc.date.available 2020-02-13T07:08:33Z
dc.date.issued 2016
dc.identifier.citation Koluman, A., Akar, N., Malkan, U. Y., & Haznedaroglu, I. C. (2016). Qualitative/chemical analyses of Ankaferd hemostat and its antioxidant content in synthetic gastric fluids. BioMed research international, 2016. en_US
dc.identifier.issn 2314-6133
dc.identifier.uri https://www.hindawi.com/journals/bmri/2016/8957820/
dc.identifier.uri http://hdl.handle.net/20.500.11851/3379
dc.description.abstract Introduction. Ankaferd hemostat (ABS) is the first topical haemostatic agent involving the red blood cell-fibrinogen interactions. The antihemorrhagic efficacy of ABS has been tested in controlled clinical trials. The drug induces the formation of an encapsulated complex protein web with vital erythroid aggregation. The aim of this study is to detect the essential toxicity profile and the antioxidant molecules inside ABS. Methods. The pesticides were analyzed by GC-MS and LC-MS. The determination by ICP-MS after pressure digestion was performed for the heavy metals. HPLC was used for the detection of mycotoxins. Dioxin Response Chemically Activated Luciferase Gene Expression method was used for the dioxin evaluation. TOF-MS and spectra data were evaluated to detect the antioxidants and other molecules. Results. TOF-MS spectra revealed the presence of several antioxidant molecules (including tocotrienols, vitamin E, tryptophan, estriol, galangin, apigenin, oenin, 3,4-divanillyltetrahydrofuran, TBHQ, thymol, BHA, BHT, lycopene, glycyrrhetinic acid, and tomatine), which may have clinical implications in the pharmacobiological actions of ABS. Conclusion. The safety of ABS regarding the presence of heavy metals, pesticides, mycotoxins, GMO and dioxins, and PCBs was demonstrated. Thus the present toxicological results indicated the safety of ABS. The antioxidant content of ABS should be investigated in future studies. en_US
dc.language.iso eng en_US
dc.publisher Hindawi Limited en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject Hemorrhage en_US
dc.subject hemostatics en_US
dc.subject blood stopper en_US
dc.title Qualitative/Chemical Analyses of Ankaferd Hemostat and Its Antioxidant Content in Synthetic Gastric Fluids en_US
dc.type article en_US
dc.relation.journal BioMed Research International en_US
dc.contributor.department TOBB ETU, Faculty of Medicine, Department of Internal Medical Sciences en_US
dc.contributor.department TOBB ETÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü tr_TR
dc.contributor.orcid https://orcid.org/0000-0001-8228-8885
dc.identifier.wos WOS:000369670100001
dc.identifier.scopus 2-s2.0-84958073903
dc.contributor.tobbetuauthor Akar, Nejat
dc.identifier.PubMedID PMID:26925418
dc.identifier.doi 10.1155/2016/8957820
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı tr_TR


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