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Browsing Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences by Submit Date

Now showing items 1-20 of 35

High serum YKL-40 level is associated with poor prognosis in patients with lung cancer

Akın Kabalak, Pınar; Çiledağ, Aydın; Demir, Nalan; Çelik, Gökhan; Yüksel, Cabir; Köycü, Gözde; Gökmen Öztuna, Derya; Rad, Abbas Yousefi; Kaya, Akın; Kutlay, Hakan; Numanoğlu Numan; Savaş, İsmail (Türk Tüberküloz ve Toraks Derneği, 2018-10-22)

High serum YKL-40 level is associated with poor prognosis in patients with lung cancer Introduction: YKL-40 is a glycoprotein that plays role in inflammation and malignant processes. High serum YKL-40 levels are associated ...
Foreign body aspiration in a pregnant woman: successfully removed roasted chickpea

Poyraz, Barış Mustafa; Alkılıç, Ayşegül; Özkan, Murat; Kasap, Servet Seçkin Tunç; Numanoglu, Numan; Tulunay, Gökhan (Turkish Assoc Tuberculosis & Thorax, 2018)

Foreign body aspiration is a serious health problem in all age groups, and in pregnancy it may cause serious complications for the fetus as well as the pregnant woman. Here we present our case of a 36 years old 22 weeks ...
Platelet to lymphocyte ratio predicts all-cause mortality in patients with carotid arterial disease.

Tek, Müjgan; Çetin, Mehmet Serkan; Diker, Erdem; Çelebi, Savaş; Amasyalı, Basri; Berkalp, Berkten (Editura Academiei Române, 2018-12-05)

BACKGROUND: Platelet to lymphocyte ratio (PLR) has been demonstrated as an risk and prognostic marker in many of cardiovascular diseases. Relationship between PLR and severity of carotid stenosis has been shown. The aim ...
Screening of Candidate Prognostic Biomarker Genes in Pediatric BCP-ALL

Bali, D. F. Akın; Öner, D. Aslar; Kürekci, A. E.; Akar, Nejat; Özdağ, H. (Wiley, 2018-11)

Background/Objectives: BCP‐ALL (B‐cell precursor acute lymphoblastic leukemia) is characterized by recurring cytogenetic and molecular genetic abnormalities. We aimed to investigate recently identified genomic risk factors ...
Frequency of thiopurine S-methyltransferase gene variations in Turkish children with acute leukemia.

Akın, Dilara Fatma; Aşlar-Öner, Deniz; Kürekçi, Emin; Akar, Mehmet Nejat (2018)

In this study we aim to determine the genotype distribution and allele frequencies of common TPMT (*2, *3A, *3B and *3C) polymorphisms in Turkish children with acute leukemia. The study population consisted of 169 patients ...
A finely resolved phylogeny of Y chromosome Hg J illuminates the processes of Phoenician and Greek colonizations in the Mediterranean

Finocchio, Andrea ; Trombetta, Beniamino ; Messina, Francesco ; D'Atanasio, Eugenia; Akar, Nejat ; Loutradis, Aphrodite; Michalodimitrakis, Emmanuel I.; Cruciani, Fulvio ; Novelletto, Andrea (Nature Publishing Group, 2018-05-10)

In order to improve the phylogeography of the male-specific genetic traces of Greek and Phoenician colonizations on the Northern coasts of the Mediterranean, we performed a geographically structured sampling of seven ...
Anammox start-up strategies: the use of local mixed activated sludge seed versus Anammox seed

Kocamemi, Bilge Alpaslan; Dityapak, Duygu; Semerci, Neslihan; Keklik, Esra; Akarsubaşı, Alper; Kumru, Mert; Kurt, Halil (Iwa Publishing, 2018-12)

The start-up period of Anammox systems is still a big challenge due to the unavailability of large volumes of slowly growing Anammox seed locally in most countries. This study aims to evaluate the effects of seeding strategy ...
Enlarging the gene-geography of Europe and the Mediterranean area to STR loci of common forensic use: longitudinal and latitudinal frequency gradients

Messina, Francesco; Finocchio, Andrea ; Akar, Nejat; Loutradis, Aphrodite; Michalodimitrakis, Emmanuel I.; Brdicka, Radim; Jodice, Carla; Novelletto, Andrea (Taylor & Francis, 2018)

Background: Tetranucleotide Short Tandem Repeats (STRs) for human identification and common use in forensic cases have recently been used to address the population genetics of the North-Eastern Mediterranean area. However, ...
Frequency of vitamin K oxidoreductase complex subunit-1 (VKORC1) polymorphisms and warfarin dose management in patients with venous thromboembolism

Kabalak, Pınar Akın; Savaş, İsmail; Akar, Nejat; Demir, Nalan; Eğin, Yonca (2018-09)

Warfarin works by inhibiting VKORC1, so polymorphisms of this gene modify the required drug dose. The aim of this study is to examine the relation between therapeutic weekly dose of warfarin and C1173T/G1639A polymorphism ...
Determination of CEBPA mutations by next generation sequencing in pediatric acute leukemia

Akın, DF; Öner, DA; Kürekci, E; Akar, Nejat (AEPress, 2018)

OBJECTIVES: The CCAAT/enhancer-binding protein-alpha (CEBPA) is lineage-specifi c transcription factor in the hematopoietic system. In this study, we aimed on the clinical features and the prognostic signifi cance associated ...
An Unusual Presentation of Kawasaki Disease: Gallbladder Hydrops and Acute Cholestatic Hepatitis

Kılıç, BO; Baysun,Ş; Gökşen, TC; Akınbingöl, İ; Arslan, Zafer (Hindawi, 2018-07-03)

Kawasaki disease is the most common vasculitis of childhood. In its classical form, at least four of five diagnostic criteria including cervical lymphadenopathy (1.5 cm or more), nonsuppurative conjunctivitis, intraoral ...
Turkish nationwide survEy of glycemic and other Metabolic parameters of patients with Diabetes mellitus (TEMD study)

Sönmez, Alper; Haymana,Cem; Bayram, Fahri; Salman, Serpil; Dizdar, Oğuzhan Sıtkı; Gürkan, Eren; Çarlıoğlu, Ayşe Kargılı; Barçın, Cem; Sabuncu, Tevfik; Satman, İlhan; Demirbaş, Berrin (Elsevier, 2018-12)

AIMS: Turkey has the highest prevalence of diabetes in Europe. It is therefore essential to know the overall cardiovascular risk and reveal the predictors of metabolic control in Turkish adults with diabetes mellitus. ...
The association of left ventricular mass index with reciprocal ST depression in STEMI

Çetin, M.S.; Çetin, E. H. Özcan; Çelebi, A. S. ; Çelebi, O. Özcan; Temizhan, A. ; Aydoğdu, S; Amasyalı, Basri (2018-08-28)

Introduction: In the pathogenesis of reciprocal ST depression in ST Elevation Myocardial Infarction (STEMI), severe and extensive coronary artery disease, presence of non-culprit obstructive lesions and larger infarct size ...
Screening of single nucleotide polymorphism in CD95 (APO-1/FAS) promoter region (G-1377A) in children with acute leukemia

Akın, Dilara F. ; Özkan, Didem T. ; Kürekci, Emin; Akar, Nejat (Wolters Kluwer Medknow Publications, 2018)

Background CD95 is a cell surface receptor involved in apoptotic signal transmission. Deregulation of this pathway results in downregulation of apoptosis and subsequent persistence of a malignant clone. A single nucleotide ...
Spatially Explicit Models to Investigate Geographic Patterns in the Distribution of Forensic STRs: Application to the North-Eastern Mediterranean.

Messina F, Finocchio A, Nejat Akar, Loutradis A, Michalodimitrakis EI, Brdicka R, Jodice C, Novelletto A (Public Library of Science, 2016-11)

Human forensic STRs used for individual identification have been reported to have little power for inter-population analyses. Several methods have been developed which incorporate information on the spatial distribution ...
Fokal Başlangıçlı Epilepside Lakozamidin Ek Tedavideki Yeri

Koç, Güray; Bek, Semai; Karadaş, Ömer; Eroğlu, Erdal; Gökçil, Zeki (Türk Epilepsi İle Savaş DerneğiTurkish Epilepsy Society, 2017-06)

INTRODUCTION: To evaluate the ef?cacy and safety of lacosamide (200-300-400 mg/day) as adjunctive treatment in patients with uncontrolled focal-onset seizures taking two or more antiepileptic drugs (AED) retrospectively. METHODS: ...
Screening of Variations in CD22 Gene in Children with B-Precursor Acute Lymphoblastic Leukemia.

Öner, Deniz Aslar; Akin DF; Sipahi K; Mumcuoglu, M; Ezer, U; Kürekci, AE; Akar N. (Mary Ann Liebert, Inc., 2016-09)

Background: CD22 is expressed on the surface of B-cell lineage cells from the early progenitor stage of pro-B cell until terminal differentiation to mature B cells. It plays a role in signal transduction and as a regulator ...
Analysis of geographical variations in the epidemiology and management of non-valvular atrial fibrillation: results from the RAMSES registry.

Doğan V, Başaran Ö, Biteker M, Özpamuk Karadeniz F, Tekkesin Aİ, Çakıllı Y, Türkkan C, Hamidi M, Demir V, Gürsoy MO, Tek Öztürk M, Aksan G, Seyis S, Ballı M, Alıcı MH, Bozyel S, Kırma C; and Collaborators. (Turkish Society of Cardiology, 2017-10)

Objective: This study aimed to determine the differences in terms of demographic characteristics and preferred stroke prevention strategies for patients with non-valvular atrial fibrillation living in seven geographical ...
Hypercalcemia of Malignancy

Çarmıklı, Berrin Demirbaş; Yener, Gül Gürsoy (Ortadoğu Reklam Tanıtım Yayıncılık Turizm Eğitim İnşaat Sanayi ve Ticaret A.Ş., 2018)

Hypercalcemia of malignancy is a common finding thypically found in patients with advanced stage cancers. Hypercalcemia has been reported to occur 20-30% of patients who have a malignancy. Hypercalcemia of malignancy usually ...
Risk factors for infection development after transrectal prostate biopsy and the role of resistant bacteria in colonic flora.

Eruz, ED; Yalci A, Ozden E, Aslaner H, Durgun SO, Taymur DD, Memikoglu KO, Erdem H, Kurt H. (Open Learning on Enteric Pathogens, 2017-02)

Introduction: In this study, we aimed to identify risk factors for the development of infectious complications after prostate biopsy and to investigate the role of intestinal colonization of bacteria that are resistant to ...