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dc.contributor.authorBayrak, Ece
dc.contributor.authorYilgor Huri, Pınar
dc.date.accessioned2019-03-25T06:46:41Z
dc.date.available2019-03-25T06:46:41Z
dc.date.issued2018-04-30
dc.identifier.citationBayrak, E., & Yilgor Huri, P. (2018). Engineering musculoskeletal tissue interfaces. Frontiers in Materials, 5, 24.en_US
dc.identifier.issn2296-8016
dc.identifier.otherArticle number 24, number of pages 8en_US
dc.identifier.urihttps://doi.org/10.3389/fmats.2018.00024
dc.identifier.urihttp://hdl.handle.net/20.500.11851/836
dc.description.abstractTissue engineering aims to bring together biomaterials, cells, and signaling molecules within properly designed microenvironments in order to create viable treatment options for the lost or malfunctioning tissues. Design and production of scaffolds and cell-laden grafts that mimic the complex structural and functional features of tissues are among the most important elements of tissue engineering strategy. Although all tissues have their own complex structure, an even more complex case in terms of engineering a proper carrier material is encountered at the tissue interfaces, where two distinct tissues come together. The interfaces in the body can be examined in four categories; cartilage-bone and ligament-bone interfaces at the knee and the spine, tendon-bone interfaces at the shoulder and the feet, and muscle-tendon interface at the skeletal system. These interfaces are seen mainly at the soft-to-hard tissue transitions and they are especially susceptible to injury and tear due to the biomechanical inconsistency between these tissues where high strain fields are present. Therefore, engineering the musculoskeletal tissue interfaces remain a challenge. This review focuses on recent advancements in strategies for musculoskeletal interface engineering using different biomaterial-based platforms and surface modification techniques.en_US
dc.description.sponsorshipTurkish Academy of Sciencesen_US
dc.language.isoengen_US
dc.publisherFrontiers Media S. A.en_US
dc.relation.isversionof10.3389/fmats.2018.00024en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTissue engineeringen_US
dc.subjectFunctional biomaterialsen_US
dc.subjectMetallic surfacesen_US
dc.subjectPolymeric surfacesen_US
dc.subjectScaffoldsen_US
dc.subjectMusculoskeletal tissue interfacesen_US
dc.titleEngineering musculoskeletal tissue interfacesen_US
dc.typearticle
dc.relation.journalFrontiers in Materialsen_US
dc.contributor.departmentTOBB ETÜ, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.contributor.departmentTOBB ETU, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.identifier.volume5
dc.identifier.wosWOS:000431193900001
dc.identifier.scopus2-s2.0-85053696057
dc.contributor.tobbetuauthorBayrak, Ece
dc.identifier.doi10.3389/fmats.2018.00024
dc.contributor.ScopusAuthorID57189465669
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR


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