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Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population

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dc.contributor.author Bilgin, Esra
dc.contributor.author Can Demirdöğen, Birsen
dc.contributor.author Türkanoğlu Özçelik, Aysun
dc.contributor.author Demirkaya, Şeref
dc.contributor.author Adalı, Orhan
dc.date info:eu-repo/date/embargoEnd/<2020-02-01> en_US
dc.date.accessioned 2019-03-27T07:20:24Z
dc.date.available 2019-03-27T07:20:24Z
dc.date.issued 2019-02-01
dc.identifier.citation Bilgin, E., Can Demirdöğen, B., Türkanoğlu Özçelik, A., Demirkaya, Ş., & Adalı, O. (2019). Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population. Neurological research, 41(2), 118-124. en_US
dc.identifier.issn 0161-6412
dc.identifier.uri http://hdl.handle.net/20.500.11851/858
dc.description.abstract Objectives: Oxidative stress is a known risk factor for the pathogenesis of atherosclerosis, the main cause of ischemic stroke. Glutathione S-transferase (GST) omega-1 and omega-2, members of phase II enzymes, play a role in the antioxidant system. The single nucleotide polymorphisms (SNPs), C419A and A424G in GST omega genes can cause a decrease in enzyme activity. The aim of this study was to investigate the possible association between these polymorphisms and ischemic stroke risk in a Turkish population. Methods: The genotypes and allele frequencies for 239 patients and 130 controls were determined by the PCR/RFLP method. No significant differences were found between patients and controls in terms of genotype and allele frequencies. Results: The frequency of the polymorphic ‘A’ allele was 0.358 in patients and 0.342 in controls for the C419A polymorphism in the GSTO1 gene. The frequency of the polymorphic ‘G’ allele for GSTO2 A424G SNP was 0.370 in patients and 0.404 in controls. The combined homozygous wild type genotype ‘CCAG’ was significantly higher in control group than in the patients. Conclusion: No significant difference was observed between the stroke patients and controls in terms of genotypes and allele distributions. Double combine haplotype CCAA was found to be protective against ischemic stroke when compare to other haplotypes. However, different genotypes of GSTO1 and GSTO2 were observed to have effects on stroke risk in subgroups of diabetics and smokers. In conclusion, the current study is the first to report this finding. en_US
dc.description.sponsorship Middle East Technical University Research Project Fund en_US
dc.language.iso eng en_US
dc.publisher Taylor and Francis Ltd. en_US
dc.relation.isversionof https://doi.org/10.1080/01616412.2018.1544385
dc.rights info:eu-repo/semantics/embargoedAccess en_US
dc.subject SNPs en_US
dc.subject stroke en_US
dc.subject ischemia en_US
dc.subject Glutathione S transferase omega 2 en_US
dc.subject Glutathione S transferase omega 1 en_US
dc.subject Genetic polymorphism en_US
dc.title Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population en_US
dc.type article
dc.type info:eu-repo/semantics/acceptedVersion en_US
dcterms.dateAccepted 2018-10-31
dc.relation.journal Neurological Research en_US
dc.contributor.department TOBB ETÜ, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümü tr_TR
dc.contributor.department TOBB ETU, Faculty of Engineering, Department of Biomedical Engineering en_US
dc.identifier.volume 41
dc.identifier.issue 2
dc.identifier.startpage 118
dc.identifier.endpage 124
dc.contributor.orcid https://orcid.org/0000-0002-1536-6123
dc.identifier.wos WOS:000459561000003
dc.identifier.scopus 2-s2.0-85057319092
dc.contributor.tobbetuauthor Can Demirdöğen, Birsen
dc.identifier.PubMedID PMID:30417762
dc.identifier.doi 10.1080/01616412.2018.1544385
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı tr_TR


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