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dc.contributor.authorYucel Cicek, Ozge Senem
dc.contributor.authorHekimoğlu, Emine Rümeysa
dc.contributor.authorTurǧal, Mert
dc.contributor.authorAtílla, Pergin
dc.contributor.authorUsubütün, Alp
dc.contributor.authorÇakar, Ayşe Nur
dc.contributor.authorBeksaç, Mehmet Sinan
dc.date.accessioned2019-03-29T06:10:45Z
dc.date.available2019-03-29T06:10:45Z
dc.date.issued2018-09
dc.identifier.citationCicek, O. S. Y., Hekimoglu, E. R., Turgal, M., Atilla, P., Cakar, A. N., Usubutun, A., & Beksac, M. S. (2018). Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles. Placenta, 69, 64-70.en_US
dc.identifier.issn01434004
dc.identifier.urihttps://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0143400418306507?returnurl=null&referrer=null
dc.identifier.urihttp://hdl.handle.net/20.500.11851/881
dc.description.abstractLeukemia inhibitory factor (LIF) and insulin like growth factor-1 (IGF-1) are two of the most important growth factors mediating trophoblast actions. We hypothesized that the localization and expression patterns of LIF and IGF-1 in partial and complete hydatidiform moles (HM) compared with normal first trimester placentas may provide an understanding of the proliferative processes in HMs. Methods: The study population included curettage material of women diagnosed as complete or partial HM as a result of histopathological and immunohistochemical examination (complete HM group, n = 8; partial HM group, n = 8) and women undergoing dilatation&curettage for unwanted pregnancies (control group, n = 8). Expression of LIF and IGF-1 among placental cell groups was evaluated immunohistochemically and given a score depending on immunostaining intensity. Results: In normal chorionic villi strong expression of LIF and IGF-1 was present. Both LIF and IGF-1 expressions were weaker in the chorionic villi of complete HMs. In complete mole decidua there was a significant decrease in glandular and endothelial IGF-1 expression along with a decrease in decidual cell LIF expression compared to normal first trimester decidua. LIF expression in extravillous trophoblasts was stronger in complete molar placentas compared to normal placentas. Discussion: LIF and IGF-1 are important regulators of trophoblast proliferation and invasion. Differential expression of LIF and IGF-1 in molar trophoblasts and chorionic villi might have a role in regulation of trophoblasts in complete moles. Decreased expression of glandular IGF-1 and decidual LIF might be related to the decidual changes during trophoblastic proliferation and invasion of decidua in complete HMs.en_US
dc.language.isoengen_US
dc.publisherW.B. Saunders Ltd.en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInsulin-Like Growth Factoren_US
dc.subjectSomatomedinsen_US
dc.subjectFetal Developmenten_US
dc.titleDifferential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform molesen_US
dc.typearticleen_US
dc.relation.journalPlacenta
dc.contributor.departmentTOBB ETÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümütr_TR
dc.contributor.departmentTOBB ETU, Faculty of Medicine, Department of Basic Medical Sciencesen_US
dc.identifier.volume69en_US
dc.identifier.startpage64en_US
dc.identifier.endpage70en_US
dc.contributor.orcidhttps://orcid.org/0000-0002-2585-7727
dc.identifier.wosWOS:000444236500009
dc.identifier.scopus2-s2.0-85050490535
dc.contributor.tobbetuauthorÇakar, Ayşe Nur
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı


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