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Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles

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dc.contributor.author Yucel Cicek, Ozge Senem
dc.contributor.author Hekimoğlu, Emine Rümeysa
dc.contributor.author Turǧal, Mert
dc.contributor.author Atílla, Pergin
dc.contributor.author Usubütün, Alp
dc.contributor.author Çakar, Ayşen Nur
dc.contributor.author Beksaç, Mehmet Sinan
dc.date.accessioned 2019-03-29T06:10:45Z
dc.date.available 2019-03-29T06:10:45Z
dc.date.issued 2018-09
dc.identifier.citation Cicek, O. S. Y., Hekimoglu, E. R., Turgal, M., Atilla, P., Cakar, A. N., Usubutun, A., & Beksac, M. S. (2018). Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles. Placenta, 69, 64-70. en_US
dc.identifier.issn 01434004
dc.identifier.uri https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0143400418306507?returnurl=null&referrer=null
dc.identifier.uri http://hdl.handle.net/20.500.11851/881
dc.description.abstract Leukemia inhibitory factor (LIF) and insulin like growth factor-1 (IGF-1) are two of the most important growth factors mediating trophoblast actions. We hypothesized that the localization and expression patterns of LIF and IGF-1 in partial and complete hydatidiform moles (HM) compared with normal first trimester placentas may provide an understanding of the proliferative processes in HMs. Methods: The study population included curettage material of women diagnosed as complete or partial HM as a result of histopathological and immunohistochemical examination (complete HM group, n = 8; partial HM group, n = 8) and women undergoing dilatation&curettage for unwanted pregnancies (control group, n = 8). Expression of LIF and IGF-1 among placental cell groups was evaluated immunohistochemically and given a score depending on immunostaining intensity. Results: In normal chorionic villi strong expression of LIF and IGF-1 was present. Both LIF and IGF-1 expressions were weaker in the chorionic villi of complete HMs. In complete mole decidua there was a significant decrease in glandular and endothelial IGF-1 expression along with a decrease in decidual cell LIF expression compared to normal first trimester decidua. LIF expression in extravillous trophoblasts was stronger in complete molar placentas compared to normal placentas. Discussion: LIF and IGF-1 are important regulators of trophoblast proliferation and invasion. Differential expression of LIF and IGF-1 in molar trophoblasts and chorionic villi might have a role in regulation of trophoblasts in complete moles. Decreased expression of glandular IGF-1 and decidual LIF might be related to the decidual changes during trophoblastic proliferation and invasion of decidua in complete HMs. en_US
dc.language.iso eng en_US
dc.publisher W.B. Saunders Ltd. en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Insulin-Like Growth Factor en_US
dc.subject Somatomedins en_US
dc.subject Fetal Development en_US
dc.title Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles en_US
dc.type article en_US
dc.relation.journal Placenta
dc.contributor.department TOBB ETÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü tr_TR
dc.contributor.department TOBB ETU, Faculty of Medicine, Department of Basic Medical Sciences en_US
dc.identifier.volume 69 en_US
dc.identifier.startpage 64 en_US
dc.identifier.endpage 70 en_US
dc.identifier.wos WOS:000444236500009
dc.identifier.scopus 2-s2.0-85050490535
dc.contributor.tobbetuauthor Çakar, Ayşen Nur
dc.contributor.YOKid 0000-0002-2585-7727
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı


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